Endocrine Abstracts

Objectives: Maternal metabolism has a major impact on foetal growth, and the risk of developing obesity, cardiovascular disease and diabetes in later life. Identification of maternal metabolic parameters in early pregnancy that predict birth weight (BW), is pivotal in the prevention of these diseases. We evaluated whether maternal triglyceride (TG) or fructosamine levels in early pregnancy, as possible reflectors of maternal insulin resistance (IR), could predominantly contrib...

Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. This therapy has been known to be highly effective in the treatment of gender dysphoria and enhancing mental health in this population.Aim: To evaluate the overall impact of GAHT on self-esteem, well-being and social/familial relations in the Portuguese adult transgender populationMethods: Cross-sectional stu...

69-year-old male, with a history of bipolar disorder under treatment, smoker and high blood pressure. He is referred for left adrenal injury detected incidentally by secondary hypertension study. Abdominal CT shows a mass of 67.7×51.8×52.3 mm in the left adrenal area, with radiological characteristics of malignancy and aggressive behavior, contacting the left renal pole and upper splenic pole, compatible with adrenal carcinoma vs. metastasis. The functional study is ...

Male, 29 years old. Go to consultations in our center for a second opinion for assessment of hypoglycemia. The patient has reported, for 3 years, symptoms consisting of episodes of dizziness and headache predominantly during the day, which subside after eating food, and which increase in frequency in relation to exercise. He provides capillary glycaemia objectified in family glucometer between 40-70 mg/dl coinciding with the episodes. The patient was initially treated at anoth...

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushing’s disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

A 38-year-old transsexual woman, with no known drug allergies, active tobacco smoker, ICAT 2. As diseases of interest, stage A2 human immunodeficiency virus (HIV) infection with current negative viral load. Lúes in 2012 treated. In treatment with Stribild (elvitegravir 150 mg/ cobicistat 150 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate 245 mg). She went to the Transsexual Persons Care Unit due to gender inconsistency since childhood with the adoption of the fem...

A 36-year-old woman in follow-up due to early ovarian failure of idiopathic origin. No family history of interest. History of menarche at 12 years of age with regular menses until 18 years of age, when it begins with amenorrheic spells lasting up to 8 months. Laboratory tests revealed hypergonadotropic hypogonadism with negative ovarian autoantibodies, normal karyotype, and gynecological ultrasound showing a normal-looking uterus with slight bilateral ovarian atrophy. Negative...

Introduction: Demand for health care for transsexual people has increased exponentially in last years, especially among adolescents and young adults. Gender-affirming hormones (GAHs) are initiated to accommodate secondary sexual characteristics to the desired sex. Published studies about metabolic repercussion of GAHs are heterogeneous and report diverse results. Our objective is to evaluate the effect of GAHs on cardiovascular risk factors in transsexual population treated in...

Introduction: Adrenal incidentalomas are a frequent finding (1.4-7.3% on abdominal CT) and increasingly common with age, obesity, diabetes and hypertension. When approaching adrenal masses, clinicians should exclude malignancy and hormonal hypersecretion. Black adrenal adenomas (BAA), first reported in 1938, are rare benign adrenocortical tumours with black/brown appearance, containing lipofuscin. Most are non-functional, rarely inducing hypercortisolism. We present a case of ...

Introduction and objectives: The inhalation of tobacco smoke leads to an acute increase in cortisol, ACTH and GH concentration, both in chronic smokers as in non-smokers. However, most studies have failed to demonstrate differences between both groups in basal levels of these hormones in plasma or urine. Additionally, cholinergic pathways have been shown to play an inhibitory role in ACTH secretion in non-smokers. UFC and circulating levels of cortisol, ACTH and GH were evalua...